pentobarbital will lower the extent or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Carefully. Coadministration of fentanyl with CYP3A4 inducers could lead to the lessen in fentanyl plasma concentrations, insufficient efficacy or, possibly, progress of a withdrawal syndrome in a very individual who's got designed physical dependence to fentanyl.
pentobarbital will reduce the extent or impact of tadalafil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. Steer clear of combination in pulmonary HTN people. For clients with ED, monitor reaction to tadalafil thoroughly on account of prospective for decreased effectiveness.
pentobarbital will lessen the level or result of fosaprepitant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
Too quick administration may lead to respiratory depression, laryngospasm, apnea, or vasodilation with fall in hypertension
pentobarbital will lessen the level or influence of nateglinide by impacting hepatic enzyme CYP2C9/10 metabolism. Use Warning/Check.
pentobarbital will lessen the level or impact of pantoprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Unfamiliar.
pentobarbital will lessen the level or outcome of fosphenytoin by impacting hepatic enzyme CYP2C9/10 metabolism. Use Warning/Keep an eye on.
pentobarbital raises effects of ifosfamide by impacting hepatic enzyme CYP2B6 metabolism. Use Caution/Keep an eye on. Coadministration of ifosfamide with CYP2B6 inducers may well raise metabolism of ifosfamide to its here metabolite. Observe for improved effects/toxicities if combined with CYP2B6 inducers.
pentobarbital will lower the level or outcome of carvedilol by affecting hepatic enzyme CYP2C9/ten metabolism. Use Caution/Keep an eye on.
pentobarbital will reduce the level or effect of bosentan by affecting hepatic enzyme CYP2C9/ten metabolism. Minimal/Importance Unfamiliar.
pentobarbital will minimize the level or impact of norgestrel by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Intently. Moderate CYP3A4 inducers could lessen progestin focus; consider utilization of more barrier techniques
fentanyl intranasal and pentobarbital both maximize sedation. Avoid or Use Alternate Drug. Limit use to patients for whom option remedy possibilities are inadequate
pentobarbital will lessen the level or outcome of bosentan by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unfamiliar.
pentobarbital will reduce the level or impact of tinidazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.